Dr. Kimberly Conlon, President of Guilford Techno Consultants, specializes in
Organic Chemistry. Her research interests are focused on combining organic chemistry with cell biological approaches to elucidate cellular processes in mammalian cells.
A noted author in her field, Dr. Conlon has researched and written extensively on the subject of cell biology. She has four Invention Disclosures to her credit and has earned the Carol M. Baldwin Breast Cancer Award from the School of Medicine at State University of New York in Stony Brook, NY.
Dr. Conlon offers
Consultation Services in the following areas:
Organic ChemistryExtraction and Purification of Biologically Active MoleculesOrganic Synthesis, Purification and Analysis of ProductsChemical Modification of Biological MacromoleculesPhotosynthetic Reactions, Site-Directed Photocleavage Reactions
Analytical ChemistryChromatographic Separations and HPLC, LC/MS/MS, LC/MS, GC/MS, UV-VIS Spectroscopy, IR Spectroscopy, MS, NMR
BiochemistryVector Cloning, Bacterially-Expressed ProteinsProtein and Nucleic Acid Biochemistry, Enzymatic Assays, Chemical ModificationPolyclonal and Monoclonal Antibodies, Immunoglobulins, IgG IsotypingImmunoassays
Cell BiologyBacterial and Yeast Cell Cultures, Insect and Mammalian Tissue CultureImmunocytochemistryWide-field Light Microscopy
The Murine DNA Glycosylase NEIL2 (mNEIL2) and Human DNA Polymerase B Bind Microtubules in Situ and in Vitro
Reactive Oxygen Species ROS have been linked to aging and the onset of several disorders ranging from cancer to Alzheime'rs disease
Cell Cycle Regulation of the Murine 8-Oxoguanine DNA Glycosylase (mOGG1): mOGG1 Associates with Microtubules During Interphase and Mitosis
8-Oxoguanine DNA glycosylase (OGG1) is a major DNA repair enzyme in mammalian cells. OGG1 participates in the repair of 8-oxoG, the most abundant known DNA lesion induced by endogenous reactive oxygen species in aerobic organisms. In this study, antibodies directed against purified recombinant human OGG1 (hOGG1) or murine (mOGG1) protein were chemically conjugated to either the photosensitizer Rose Bengal or the fluorescent dye Texas red.
Site-directed Photoproteolysis of 8-Oxoguanine DNA Glycosylase 1 (OGG1) By Specific Porphyrin-Protein Probe Conjugates: A Strategy to Improve The Effectiveness of Photodynamic Therapy for Cancer
The specific light-induced, non-enzymatic photolysis of mOGG1 by porphyrin-conjugated or rose bengal-conjugated streptavidin and porphyrin-conjugated or rose bengal-conjugated first specific or secondary anti-IgG antibodies is reported.
