The Title of this publication as "Drug Injury", allows a wide range of sub-topics and an almost endless level of health related information. Thus, the inclusion of this Chapter is a de facto statement that Marijuana/Cannabinoids are an integral part of our Drug Lexicon. Historically, the Medical/Drug aspect of Marijuana is well documented in the On-Line entity at ProCon.org as recently as 08/13/2013. And, lest the reader retain some skepticism as to the Drug categorization of Marijuana/Cannabinoids, our U.S. Government was issued a Patent # 6630507 in Oct. 2003 for Marinol. This synthetic Cannabinoid Drug had a recommendation as "cannabinoids as antioxidants and neuroprotectants". This Patent stands not withstanding the statement of "no medical use" for Marijuana in the 1970 placement as a Schedule 1 substance in the Controlled Substance Act. And, even more incredulous, given the 1937 Marijuana Stamp Act that established Marijuana as an Illegal Substance.
Pharmacogenomics is a field that studies genetic differences in sensitivity to therapeutically used drugs. We have learned that some medications are not effective in some individuals, or super effective and even likely to result in adverse effects in others due to genetic polymorphisms. Similarly, toxicogenomics investigates sensitivities with toxic chemicals, including carcinogens.
In the absence of physical evidence or eyewitness testimony, establishing a criminal charge of child sexual abuse often boils down to a “he said, she said” weighing of credibility of the accuser and accused. As the burden of proof lies on the prosecution to establish the charge beyond a reasonable doubt, witness testimony becomes paramount in determining the outcome of the case. If the alleged victim is suffering from a serious mental illness, such as psychosis, that impairs one’s ability to either accurately recall the alleged abuse or distinguish reality from fantasy, witness credibility will suffer, and the defendant will likely be found not guilty. For both plaintiff and defense counsel, when there is any suspicion of psychotic illness in the accuser, it is critical to assess the following before trial: type and severity of mental illness, genetics, drug use, previous abuse, and neglect.
Cocaine remains a popular drug of abuse, and per HHS (2008) of 6.5 million US Federal workplace drug tests, about 40,000 were positive for cocaine in 2007. Drug testing for cocaine is based on the metabolite benzoylecogonine which is detectable in the user’s urine for 24 hours, possibly even up to 72 hours. Non-metabolized cocaine may only be detectable for 4-6 hours following use, making it a less useful target in a drug testing program.
Presumptive tests, also known as preliminary tests or field tests, allow drugs to be quickly classified into a particular chemical group, but do not unequivocally identify the presence of a specific chemical compound. Preliminary drug test results are often included in a panel of tests, which then be used as a guide to an appropriate confirmatory test to determine and verify the chemical compounds present.
To be, or not to be, intoxicated! The expert witness-consultant is frequently confronted with this question in litigation matters relative to alcohol in the human body under diverse circumstances. Even given a diverse range of circumstances, the basic information can be encompassed as follows:
The currently most frequently requested tests, or, analytes in the Drugs of Abuse category are listed below. However, as will be discussed later in this report, there are other designations that refer the these same drugs or drug classes. Furthermore, if one were to make an exhaustive listing of all of the many "Street Names" for these available drug products, the listing would have several hundred entries.
Nongenotoxic bladder carcinogens that form bladder calculi have been concluded to be of low carcinogenic risk to humans because bladder stones would be expelled or surgically removed before they had a chance to exert their carcinogenic effect.
Hydrogen sulfide and sulfur dioxide are two sulfur-based gases that exhibit entirely different toxicological characteristics. Litigation issues involving these two gases are as different as are their disparate toxic effects in humans